Author(s): Jay K Desai, Bhavesh J Trangadia, Urvesh D Patel, Mayank H Kariya, Radhey Shyam Chauhan, Seema K Bishnoi and Dilip Singh Meena

Abstract: 4-nonylphenol (4-NP) is a phenolic chemical that disrupts the endocrine system and is used in a range of industrial goods. It poses a health hazard to both humans and aquatic animals. A total of 216 adult male zebrafish (Danio rerio) were used in the research to examine the harmful effects of 4-NP on the eyes of zebrafish. The fish were exposed to 4-NP on a daily basis for a duration of 21 days. The zebrafish were placed into four groups for the experiment: control group (C₁), vehicle group (C₂), treatment 1 group (T₁), and treatment 2 group (T₂). Each group consisted of 54 zebrafish. The C₁ group was exposed to reverse osmosis water, while the C₂ group was exposed to water containing 100% ethanol as a vehicle at a concentration of 10 μl/L. The T₁ and T₂ groups were exposed to water containing 4-NP at concentrations of 100 μg/L and 200 μg/L, respectively. The T₁ and T₂ groups exhibited a notable reduction in the activity of SOD and the level of GSH in the eye, compared to the C₁ group. However, the T₂ group showed a large rise in MDA level compared to the C₁ group. The CAT activity in the T₁ and T₂ groups is significantly reduced in the eye compared to the C₁ group.

DOI: 10.33545/26174693.2024.v8.i1c.333