International Journal of Advanced Biochemistry Research

Biochem
Journal

Printed Journal   |   Indexed Journal   |   Refereed Journal   |   Peer Reviewed Journal

Vol. 8, Issue 1, Part C (2024)

An assessment of the oxidative stress caused by 4-nonylphenol in the eyes of adult male zebrafish

Author(s): Jay K Desai, Bhavesh J Trangadia, Urvesh D Patel, Mayank H Kariya, Radhey Shyam Chauhan, Seema K Bishnoi and Dilip Singh Meena
Abstract: 4-nonylphenol (4-NP) is a phenolic chemical that disrupts the endocrine system and is used in a range of industrial goods. It poses a health hazard to both humans and aquatic animals. A total of 216 adult male zebrafish (Danio rerio) were used in the research to examine the harmful effects of 4-NP on the eyes of zebrafish. The fish were exposed to 4-NP on a daily basis for a duration of 21 days. The zebrafish were placed into four groups for the experiment: control group (C1), vehicle group (C2), treatment 1 group (T1), and treatment 2 group (T2). Each group consisted of 54 zebrafish. The C1 group was exposed to reverse osmosis water, while the C2 group was exposed to water containing 100% ethanol as a vehicle at a concentration of 10 μl/L. The T1 and T2 groups were exposed to water containing 4-NP at concentrations of 100 μg/L and 200 μg/L, respectively. The T1 and T2 groups exhibited a notable reduction in the activity of SOD and the level of GSH in the eye, compared to the C1 group. However, the T2 group showed a large rise in MDA level compared to the C1 group. The CAT activity in the T1 and T2 groups is significantly reduced in the eye compared to the C1 group.
Pages: 186-190  |  228 Views  118 Downloads


International Journal of Advanced Biochemistry Research
How to cite this article:
Jay K Desai, Bhavesh J Trangadia, Urvesh D Patel, Mayank H Kariya, Radhey Shyam Chauhan, Seema K Bishnoi, Dilip Singh Meena. An assessment of the oxidative stress caused by 4-nonylphenol in the eyes of adult male zebrafish. Int J Adv Biochem Res 2024;8(1):186-190. DOI: 10.33545/26174693.2024.v8.i1c.333
International Journal of Advanced Biochemistry Research
Call for book chapter