Vol. 9, Special Issue 8, Part K (2025)

The silkworm, Bombyx mori L., is an economically important insect serving as primary producer of silk and supporting the livelihoods of millions involved in sericulture. However, the extensive use of pesticides in agricultural fields often exposes silkworms to harmful residues through contaminated mulberry leaves, air or soil. Such exposure can cause significant physiological, biochemical and structural damage in the silkworm, ultimately affecting silk production and quality. Among the adverse effects, histopathological changes in vital tissues provide critical insights into the toxic impact of insecticides at the cellular and tissue level. This review synthesizes current knowledge on the histopathological alterations in silkworm tissues such as midgut, silk glands and gonadal exposure to different classes of pesticides. The mechanisms underlying tissue damage, including oxidative stress, enzyme inhibition and cellular necrosis are discussed. Understanding these effects is essential for developing sustainable pest management strategies that minimize risks to silkworm health and sericulture productivity.