Vol. 9, Special Issue 1, Part F (2025)

Chemically, Oleanolic acid (OA) is a natural pentacyclic triterpenoid abundant in the olive family. The therapeutic potential of OA has been evaluated in obesity, dyslipidemia, hypertension, and hyperglycemia, as well as, in anticancer activity. Moreover, OA is used to fabricate semi-synthetic triterpenoids in terms of high solubility, bioavailability, and efficacy for the therapeutic application of chronic disorders. Numerous derivatives of OA have been synthesized by researchers through significant alteration in the OA, less cytotoxic chemotherapeutic agents in lung cancer. CDDO (2-cyano-3,12-dioxooleana-1, 9 (11)-dien-28-oic acid) has been approved in clinical trials and many more are under the pipeline. SZC017has been reported against the lung cancer cell line. Previous results exhibit that OA and its analogue have a remarkable potential to arrest the abnormal cell growth of pulmonary metastasis, induce apoptosis and autophagy, regulate cell cycle regulatory proteins, inhibition of cancer cell migration and invasion.