Vol. 8, Special Issue 8, Part O (2024)

Materials and Methods: The study was conducted over a period of six months among the subjects having hypothyroidism at Narayana Medical College & Hospital.

The study includes 70 hypothyroid who attended OPD or were admitted to the wards. The cases taken for study belonged to the age group of 35- 60 years including both female and male subjects. 30, healthy individuals working in Narayana Medical College in the age group of 35- 60 were included in the control group.

Blood samples were collected and serum was separated by centrifugation and used for the estimation of Thyroid profile, Ferritin, MDA, Uric acid, and Zinc.

Conclusion: Hypothyroidism, hyperthyroidism. Hypothyroidism is one of the major problems in humans lack of secretion of thyroid hormone from the thyroid gland as a biologically active form of T₃ and T₄ oxidative stress is also one of the factors for hypothyroidism in hypothyroidism condition the GFR is very low and leads to uric acid clearance is low this result in hypothyroidism and hyperuricemia is observed. Iron absorption of the iron 1 binding protein Fe2+ and protein (Ferritin) levels is also very low in hypothyroidism condition Zn+ is also a very important mineral in thyroid hormone metabolism and improves the anti-oxidant mechanism in humans. In hypothyroidism patients lack of Zn+ absorption leads to low levels of Zn+ is observed in hypothyroidism patients.