Author(s): Mayur Purankar, Alka Sawarkar, Somkuwar AP, Madhuri Hedau, Manoj Patil and Swati Umap

Abstract: Neolamarckia cadamba is a medicinal plant reported for various medicinal properties. Anticancer activity of methanolic extract of stem bark of Neolamarckia cadamba on DMBA-induced diabetes and serum biochemical studies were conducted in Wistar rats. Group T₁ is designated as the standard control, Group T₂ was positive control, i.e. orally administered with DMBA at a dose rate of 20 mg/kg body weight three times a week for five weeks, Group T₃ was treated with the standard reference drug Tamoxifen at a dose rate of 3.3 mg/kg body weight and Groups T₄ and T₅ were treated with methanolic bark extract of Neolamarckia cadamba at a dose rate of 200 and 400 mg/kg body weight, respectively. The observation obtained from ultrasonography examination of rats after the completion of treatment revealed that all the treatment groups (T₃, T₄, T₅) showed that there was regression of the mammary tumour. On the 30th day, Tamoxifen @ 3.3 mg/kg decreases (p<0.05) the BUN and serum protein levels effectively compared to the T₄ and T₅. It is noticed that the T₂ group positive control showed a steady increase in estrogen and progesterone levels, while the T₃ group showed a significant decline as compared to the T₄ and T₅. The Std reference drug tamoxifen group showed effectiveness compared to the Neolamarckia cadamba extract dosages 200 mg/kg (T₄) and 400 mg/kg (T₅).

DOI: 10.33545/26174693.2024.v8.i4Se.1016