Author(s): Neeraj Kumar, Munish Batra, Manish Kumar Verma, Jitendra Singh and Ramswaroop Singh Chauhan

Abstract: The present study was conducted to know the effects of nanosilver (AgNPs) administration at NOAEL dose on biochemical parameters in Wistar rats for a period of 90 days. Thirty-five, 6-weeks-old, Wistar rats of both the sexes were divided randomly in two groups. Group 1 was kept as control and comprising of 20 rats. Group II was comprising of 15 rats and were orally administered silver nanoparticle mixed in distilled water orally at NOAEL dose rate of 30 mg/kg body weight/day from 0 day of experiment till 90^th days post treatment (DPT). Blood was collected from 5 rats from each group at 0 (only from group I), 30^th, 60^th and 90^th DPT and serum was used for biochemical studies. In group I rats, there was no significant change in any biochemical parameter at any DPT. Group II rats revealed significance increase in value was observed in ALT, AST, and cholesterol at 30^th, 60^th and 90^th DPT as compared to group I rats. While total serum protein, serum albumin, serum gamma globulin and serum globulin levels were significantly decreased at 90^th DPT in treated group as compared to control group. Serum glucose levels were also decreased at 30^th, 60^th and 90^th DPT in treated group as compared to control. There was no significance difference in the serum calcium and serum phosphorus level in group I & II rats at any time interval. It can be concluded from the present studies that nanosilver exerted adverse effects on biochemical parameters of Wistar rats at NOAEL dose for a period of 90 days.

DOI: 10.33545/26174693.2024.v8.i3Sg.819