Author(s): Ymberzal Koul, Ravina, Chandana Sree Chinnareddyvari, Dharamshaw CA, Pallavi Rathi, Rangasai Chandra Goli and Kiyevi G Chishi

Abstract: Amla, also known as Indian gooseberry, has been revered in Ayurveda for its rejuvenating properties and extensive use in traditional formulations like Triphala and Chyavanaprasha. This fruit is rich in phytochemicals such as quercetin, gallic acid, tannins, flavonoids, and vitamin C, which have long been recognized for their medicinal properties. These compounds contribute to its diverse therapeutic potential, accumulated over centuries of ethnomedical use and documented in ancient texts. Contemporary pharmacological studies have corroborated its traditional uses, demonstrating Amla's antioxidant, anticarcinogenic, antitumor, antigenotoxic, and anti-inflammatory activities. These findings underscore its broader applicability in modern medicine. Moreover, research into Amla's phytochemical complexity, including terpenoids, alkaloids, flavonoids, and tannins, highlights its versatility in addressing various health concerns. Computational docking studies have delved into the molecular interactions between Amla's bioactive compounds and specific target proteins, revealing insights into its mechanisms of action at the molecular level. In this study, receptor proteins associated with metabolism were selected and interaction studies were performed with Emblica officinalis using Autodock Vina 1.5.6 software. Quercetin showed affinity for inflammatory mediators like cyclooxygenase (COX) and lipoxygenase (LOX), suggesting potential anti-inflammatory effects, gallic acid with cell cycle regulators like cyclin-dependent kinases (CDKs), indicating its potential antiproliferative effects on cancer cells. Tannins have been studied for their inhibitory effects on enzymes involved in carbohydrate metabolism, offering potential benefits for diabetes management. Overall, Amla emerges as a promising source of therapeutically valuable products, with its well-documented pharmacological properties and favorable safety profile. Continued research efforts will further unlock its potential applications in contemporary healthcare.

DOI: 10.33545/26174693.2024.v8.i3Sg.800