Author(s): Ravina, Gaurav Patel, Chandana Sree Chinnareddyvari, Dharamshaw CA, Pallavi Rathi, Rangasai Chandra Goli and Kiyevi G Chishi

Abstract: Single nucleotide polymorphisms (SNPs) play a pivotal role in genetic variation, particularly in missense variants that can significantly impact protein function. This study focused on the FecB gene, also known as BMPR1B, in sheep, which is critical for various physiological processes, particularly in reproduction. By analyzing SNP data retrieved from Ensembl-Biomart and Uniprot databases, we identified missense variants and utilized in silico tools to predict their deleterious effects and impact on protein stability. We found common deleterious mutations, P482L and R469K, which were predicted to decrease protein stability. Additionally, protein-protein interaction analysis revealed associations between FecB and proteins involved in important biological pathways. These findings contribute to our understanding of genetic variations in the FecB gene and their potential implications for sheep health and reproduction.

DOI: 10.33545/26174693.2024.v8.i3Sd.725