Author(s): M Champawat, LN Sankhala, P Sharma, A Gaur and Hemvati

Abstract: Cefquinome, a fourth generation cephalosporin, having broad spectrum of activity against Gram-positive and Gram-negative bacteria and developed exclusively for veterinary use. Non-steroidal antiinflammatory drugs (NSAIDs) are commonly used with antimicrobial therapy in veterinary practice for the treatment of infectious diseases. The present study was taken to investigate the disposition kinetics of cefquinome at the dose rate of 2 mg kg-1 body weight and the effect of flunixin when co-administered intravenously at the dose rate of 2.2 mg kg-1 body weight on disposition kinetics of cefquinome in goats. Plasma concentrations were determined by microbiological assay method using MTCC equivalent (MTCC 1541) of Micrococcus luteus (ATCC 9341) as the test organism. Following intramuscular administration of cefquinome, the plasma concentration time profile was best described by one compartment open model. In the present study, following intramuscular administration of cefquinome in flunixin pretreated goats, the peak plasma concentration (Cmax) was observed 4.48±0.19 μg ml-1 which was not significantly higher and almost comparable to the Cmax 5.1±0.51 μg ml-1 observed in only cefquinome administered goats. Following co-administration of cefquinome with flunixin, no significant changes were observed in most of the pharmacokinetic parameters of cefquinome, except elimination half-life (t1/2β) and volume of distribution (Vdarea) which were significantly increased. The integration of pharmacokinetic and pharmacodynamics parameters suggested that the cefquinome at the dose rate of 2 mg kg-1 body weight intramuscularly can be administered with flunixin to treat bacterial infections with inflammatory conditions in goats.

DOI: 10.33545/26174693.2024.v8.i1Si.389