Vol. 8, Special Issue 10, Part M (2024)

This study investigates the effects of ethion, a commonly used organophosphate pesticide, and silver nanoparticles (AgNPs) on serum biochemical parameters in developing avian embryos. Ethion treatment resulted in significant hepatotoxicity, evidenced by elevated serum levels of liver enzymes (SGOT, SGPT, ALP) and dysregulated lipid profiles, including increased total cholesterol, triglycerides, and LDL-C, with a corresponding decrease in HDL-C. In contrast, low doses of AgNPs demonstrated a protective effect, normalizing these biochemical parameters and enhancing HDL-C levels, likely due to their antioxidant properties. However, higher doses of AgNPs induced toxicity, exacerbating liver dysfunction and lipid abnormalities. The findings highlight the potential of AgNPs as a therapeutic agent to mitigate pesticide toxicity, while also underscoring the importance of dosage optimization to avoid adverse effects. This research contributes to the understanding of the interplay between pesticides and nanomaterials in avian health, advocating for further exploration into their combined effects for improved environmental and animal welfare.