Vol. 9, Issue 9, Part C (2025)

Background: Toxic effect arising from a mixture of chemicals can affect different brain areas thus weakening the overall defense mechanisms and leading to cumulative damage and neuronal death. Using MPTP (as a positive control) at unreported low dose (7 mg/kg b.w), we studied its interactive effect with Monocrotophos (MCP) in different treatment patterns (co-treatment and post-treatment) to ask if a compromised striatum is susceptible to environmental stressors (appearing in low or unreported doses). Evaluations were drawn in terms of neurobehavioral deficits, levels of DA, AChE, markers of oxidative stress and markers of mitochondrial and nitrate stress in the mice striatum. 
Methodology: Two treatment patterns of MCP with MPTP were chosen. In the first, MCP was dosed at 0.3 mg / kg b.w on the day 1 along with MPTP (co-treatment) at 7 mg / kg b.w distributed as 4 i.p injections every 2h for 8h on the same day, then followed by MCP oral dosing for 7 days. In the second treatment pattern, MCP was dosed at 0.3 mg / kg b.w for 7 days followed by administration of MPTP (post-treatment) at the above mentioned dose on day 8th. 
Results: Post-treatment schedule showed a significant reduction in levels of dopamine, acetylcholine esterase, increased in ROS & LPO, decrease in striatal mitochondrial ATP and complex 1 with no apparent effect on the nitric oxide content. 
Conclusion: Our data shows that a compromised striatum is susceptible to environmental stressors that usually appear in low or unreported doses.