Vol. 9, Issue 9, Part B (2025)

The present study is aimed to develop spinal cord injury by employing orthopaedic mini-drill and investigate neuroprotective effects of the herb Tanacetum parthenium after injury by the means of histopathological and immunohistochemical observation. A total of 48 male Wistar rats were divided into positive control (To), spinal cord injury group (T-ve group) and spinal cord injury with treatment of Tanacetum parthenium (T). Histopatholgical examinations were performed to understand the various changes at tissue and cellular level in multiple organs and spinal cord. Results showed axonal disruption, astrocytosis, and cavitation. Neuronal repair was noticed. There was progressive reduction in the inflammation in organs and spinal cord indicating anti-inflammatory effects of the herb. Regeneration was absent, indicating no potential effect of the herb on nerve regeneration. All the rats exhibited inability to void urine voluntarily. These findings suggest that orthopaedic-mini drill induces complete paraplegia and is an adaptable and reproducible technique. However, no neural protective effects were exhibited by the herb Tanacetum parthenium.