Vol. 9, Issue 9, Part A (2025)

The study one was aimed to determine the haematological, clinical, biochemical, histopathological changes occurred due to aflatoxicosis in white pekin ducklings and its amelioration by n-acetyl cysteine (NAC). A total of 120, day old ducklings, of old white pekin variety were randomly selected and divided into four groups of 30 ducklings of in each group, having 3 replicas of 10 each. The group 1 was considered as control group and were fed with normal basal diet and water daily for 28days. Aflatoxin (AF) was added at the rate 100 ppb in remaining all group. NAC was added to feed of group 3 and group 4 ducklings at the rate 3.2 and 5.2 gm/kg body weight. The ducklings were found dull, depressed, anorectic and showed signs of lameness. At 28th day after the administration of aflatoxins, blood samples were collected for biochemical and haematological analysis. Group 2 ducklings showed increased serum enzyme levels like ALP, AST, ALT, creatinine and urea in comparison to control ducklings. In group 3 slight decrease in serum AST, ALT, ALP, Urea and creatinine levels as compared to group 2 that is aflatoxin treated group. There was significant increase in malondialdehyde (MDA) levels in different organs and decrease in Aflatoxin induced (ROS) along with marked decrease in CAT, GPx, and SOD levels. The increase in serum levels of ALT, AST, ALP, creatinine and urea levels were also noticeable. In group 2. Histopathological changes were observed like vacuolar degeneration in liver, mild congestion in liver, increased bowman space in glomeruli of kidney, necrosis and degeneration of tubular epithelial cells of kidney. But group 3 and 4 ducklings showed improvement in gross and histopathological changes are less severe. Present study revealed thr usefulness of NAC administration for the treatment of aflatoxicosis in ducklings.