Vol. 9, Issue 8, Part E (2025)

The antidiabetic effects of aqueous seed extract of Ficus benghalensis Linn laticiferous bark extract was examined and evaluated in diabetes mellitus induced albino wistar rats using alloxan monohydrate, which was also compared with hypoglycemic and hypolipidemic effects of glibenclamide. The selected standard drug is generally used in diabetes mellitus treatment. It is available in tablets for humans as well as canines. These selected drug was studied systematically, analyzed and compared with Ficus benghalensis plant extract. For induction of diabetes, male albino wistar rats of average weight about 120 gm were intraperitoneally administered with alloxan monohydrate, a crystal pink powder, dissolved in cold NS, at the dose rate of 120 mg/kg BW. Alloxan was used in all rats except negative control group. Diabetes induction was confirmed by evaluating the blood glucose levels. The blood glucose level of selected rats for this study was about 160 mg/dL. Rats of Group I served as normal control and rats of Group II served as hyperglycemic control. Group III rats were given Glibenclamide in 1 ml of aqueous solution at a dose rate of 10 mg/kg BW p.o.; Group IV rats were orally administered Ficus benghalensis Linn laticiferous sap at the dose rate of 0.25 g/kg BW, given in 1ml of diluted aqueous dilution. Group V was orally given Ficus benghalensis Linn laticiferous sap at the dose rate of 0.50 g/kg BW diluted in 1ml aqueous solution. Group VI was orally given Ficus benghalensis Linn laticiferous sap at the dose rate of 0.75 g/kg BW diluted in 1ml aqueous solution. Alloxan induced diabetic rats of Group II showed increase in the levels of total cholesterol, serum triglycerides, serum creatinine, blood urea nitrogen and blood glucose till the end of this study. Group III were treated with standard drug Glibenclamide at a dose 10 mg/kg BW significantly reduced the elevated blood glucose level, total cholesterol, serum triglycerides, serum creatinine; while blood urea nitrogen (BUN) level was restored to near the normal range. In group IV, administration of Ficus benghalensis Linn laticifarous sap at a dose 0.25 g/kg BW significantly reduced the elevated blood glucose level, total cholesterol, serum triglycerides, serum creatinine and serum blood urea nitrogen (BUN) level. In group V, Ficus benghalensis Linn laticifarous sap administration at a dose 0.50 g/kg BW significantly reduced the elevated blood glucose level, total cholesterol, serum triglycerides, serum creatinine and serum blood urea nitrogen (BUN) was restored near to the normal range. In group VI Ficus benghalensis Linn laticifarous sap administration at a dose 0.75 g/kg BW significantly reduced the elevated blood glucose level, total cholesterol, serum triglycerides, serum creatinine and serum blood urea nitrogen (BUN) was restored near to the normal range. Results showed that Ficus benghalensis Linn laticifarous sap showed both hypoglycemic and hypolipidemic effect. There is further scope in study for the advancement of the drug discovery for the treatment of diabetes mellitus using its other parts and qualitative analysis of its phytochemical constituents.