Vol. 9, Issue 7, Part Q (2025)

The effect of ethanol extract of Garcinia kola seed on lipid profile in doxorubicin-induced cardiotoxicity in wistar rats was investigated in this study. Cardiotoxicity was induced by the administration of doxorubicin (DOX) to male Wistar rats in six equal injections intraperitoneally, over two weeks (cumulative dose, 15 mg/Kg body weight). The protective effect against doxorubicin-induced oxidative injury was studied by oral administration of Garcinia kola seed (GK) at 250 mg/kg body weight and 500 mg/kg b.wt respectively in 14 equal doses over four weeks (2 weeks before and 2 weeks concurrently with doxorubicin). At the end of the treatment, serum lipid profile was assayed. Results obtained from the study showed that treatment with doxorubicin significantly (p<0.05) increased serum cholesterol compared to control. There was no significant difference among rats in NC, DOX+GK 500, and G. kola groups, while DOX+G. Kola 500 mg, G. Kola and DOX groups showed no significant differences among them. Doxorubicin treatment resulted in the elevation of Total non-HDL-cholesterol (50.8±12.09mg/dl) which was significantly (p<0.05) higher compared to normal control (32.35±2.78mg/dl) and 27.5±3.65, 42.81±6.09, 40.38±5.62, 34.13±3.59 mg/dl in G. kola 500 mg, DOX + G. kola 250 mg, DOX + G. kola 500 mg and DOX + Simvastatin (SIM) treated groups respectively. Also, there was the elevation of LDL/HDL ratio to 0.62±0.29 which was significantly higher than the Normal control group (0.39±1.4). Treatment with G. kola 500 mg, DOX + G. kola 250 mg, DOX + G. kola 500 mg, and DOX+SIM resulted in a significant reduction of LDL/HDL ratio to 0.19±0.04, 0.36±0.13, 0.54±0.24, 0.24±0.06 respectively in the exposed animals respectively. Administration of the ethanol extract of Garcinia kola seed before and concurrently with doxorubicin, resulted in significant lipid-lowering properties; indicating a cardioprotective effect against doxorubicin-induced cardiotoxicity.