Vol. 9, Issue 3, Part C (2025)

Biochemical alterations often accompany multi-organ damage, a condition primarily induced by hypertension. This study investigated plasma levels of total protein, albumin, C-reactive protein (CRP), and trace elements (Mn, Ca, Zn, Se, Mg, Fe) in juvenile hypertensive patients (n=30) compared to normotensive controls (n=30) in Ekiti State, Nigeria. Venous blood samples were collected after overnight fasting, and plasma was analyzed using standard methods. No significant differences (p>0.05) were observed in total protein, albumin, Mn, Zn, or Fe. However, juvenile hypertensive patients exhibited significantly higher CRP (p<0.05), Ca (p<0.05), and Se (p<0.05), and significantly lower Mg (p<0.05) compared to controls. These findings suggest the presence of inflammation and altered mineral homeostasis in juvenile hypertension, potentially contributing to its etiology and informing management strategies.