Vol. 9, Issue 3, Part A (2025)

Cystic endometrial hyperplasia-pyometra complex (CEH-P) is the most frequent uterine disorder observed in intact bitches. Pathophysiological aspects of CEH-P includes bacterial infection in endometrium due to the influence of progesterone. In the present case study 12 bitches with pyometra and endometritis were treated with harmonal treatment of antiprogesterone, prostaglandin and were given broad spectrum antibiotics. Out of 12 cases, 9 bitches recovered successfully while in 2, ovariohysterectomy was performed after the instituting treatment and one death was recorded. Response to the treatment was seen according to ultrasonography and general condition included termination of uterine discharge, reduced progesterone level, decline in uterine diameter and also WBC count within 15 days of treatment. All 9 recovered bitches subsequently experienced normal estrus. The result demonstrated that antiprogesterone drug along with prostaglandin and broad spectrum antibiotics was effective in 9 bitches (75%) with pyometra and endometritis causing no side effects. In conclusion antiprogesterone and prostaglandin and broad spectrum antibiotics is useful for treating bitches with pyometra and endometritis.