Vol. 9, Issue 11, Part A (2025)

The present study was carried out to evaluate the protective effects of quercetin (@ 50 & 100 mg/kg body weight) in meloxicam (@ 2.1 & 4.2 mg/kg body weight) induced haematological and biochemical alteration in Wistar rats (n = 56) for 28 days. In groups I to VII animals were administered with and respectively. There was a significant decrease in values of haemoglobin, packed cell volume, platelets, total erythrocyte count and significant increase in neutrophil count in group II and III (meloxicam @ 2.1 & 4.2 mg/kg) in comparison with control group (0.5 mL of carboxy methyl cellulose). Moreover, group treated with quercetin at dose rate of 100 mg/kg body weight. (groups V and VII) along different doses of meloxicam (2.1 mg/kg body weight. and 4.2 mg/kg body weight.) showed significant (p<0.05) increase in values of TEC, Hb, PCV, MCV, MCH, MCHC, lymphocyte and platelet count as well as decrease in values of TLC, neutrophils in comparison to group treated with high dose of meloxicam. The concentration of AST, ALT, triglyceride, cholesterol and BUN increased significantly (p<0.05) and total protein as well as albumin value decreased (p<0.05) significantly in rats of group III treated with meloxicam at dose rate of 4.2 mg/kg body weight./Day. In group II, significant (p<0.05) increase in concentration of AST decrease values of total protein and albumin were noted. The creatinine value did not differ significantly among all groups. In quercetin co-administered groups (groups IV, V, VI and VII), restoration in serum values of AST, ALT, triglyceride, cholesterol, BUN, total protein and albumin were noted suggesting ameliorative effect of quercetin on liver and kidney toxicities.