Vol. 9, Issue 10, Part E (2025)

The present study was conducted on pancreas of domestic animals i.e 15 adult buffalo, 19 sheep, 18 goats 9 dogs and 17 pigs of either sex. The hormones were synthesized by the cells of islets of Langerhans. They include glucagon (α-cells), insulin (β-cells) and somatostatin (δ-cells) immunoreactive cells. The glucagon immunoreactive (IR) cells were predominantly located at the periphery of the islets of Langerhans in buffaloes, sheep, goat and pig while center of islets of Langerhans in dog. The insulin IR cells (β-cells) were distributed throughout the islets, with a higher frequency in the center, and were the most abundant cell type in all species. While, the somatostatin IR cells (δ-cells) were present at the periphery of the islets, often adjacent to glucagon and insulin IR cells, and were the least abundant cell type. Some endocrine cells were present as isolated individual cells or 2 or 3 cells in the parenchyma between the acini and epithelium of inter and intralobular ducts.