Vol. 9, Issue 1, Part L (2025)

This study aims to focus on serum levels of L-carnitine, insulin, high sensitivity C-reactive protein (hs-CRP), fasting serum glucose FSG, Homeostatic Model Assessment-Insulin Resistance HOMA-IR in type2 Iraqi diabetic patients compared with apparently healthy controls. A case-controlled study included (84) Iraqi subjects were classified into two groups: diabetics (45) and controls(39). L-carnitine and insulin levels were significantly (p˂0.05) lowered in diabetics as compared to controls, while high sensitivity C-Reactive Protein (hs-CRP), FSG, HOMA-IR were significantly (p˂0.05)elevated in their serums, furthermore, the serum insulin levels have a positive significant correlation with serum L-carnitine levels in both groups, illustrating the influence of L-carnitine in ameliorating diabetes risks by improving glucose level, and ameliorate insulin resistance, beside their anti-inflammatory effect. These findings suggest using of L-carnitine as a therapy in diabetes mellitus and insulin resistance.