Vol. 8, Issue 8, Part L (2024)
6S RNA: A key player in transcriptional regulation
Author(s):
Dr. Tasmiya Imtiyaz
Abstract:
Transcription is a fundamental process in all biological systems and forms a major step in the central dogma of life. In prokaryotic cells, transcription is catalyzed by RNA polymerase (RNAP), which is subjected to a complex regulatory network. The activity of RNAP is controlled by a variety of molecules, including proteins, low-molecular compounds, and nucleic acids. Among these, bacterial 6S RNA is a prime example of transcriptional regulation through non-coding RNA. 6S RNA, a small RNA regulator of RNAP, is present throughout the bacterial kingdom. Studies in Escherichia coli revealed that 6S RNA forms a complex with RNAP, resulting in the regulation of transcription, and cells lacking 6S RNA exhibit altered survival phenotypes. 6S RNA functions by modulating protein activity or sequestration, directly impacting transcription. This article explores the discovery, structure, mechanism, and biological significance of 6S RNA, emphasizing its role as a global regulator in optimizing bacterial survival during nutrient limitation.
Pages: 946-947 | 277 Views 112 Downloads
How to cite this article:
Dr. Tasmiya Imtiyaz. 6S RNA: A key player in transcriptional regulation. Int. J. Adv. Biochem. Res. 2024;8(8):946-947. DOI: 10.33545/26174693.2024.v8.i8l.1907