Vol. 8, Issue 7, Part m (2024)

Abstract: This study investigated the effect of aqueous extract of Datura stramonium (DS) on the activities of the enzymes involved in carbohydrate metabolism. Twenty five animals were distributed into 5 groups of 5 animals each, Doses (50, 100, 200 and 400 mg/kg bodyweight) of aqueous extract of DS were given orally for 28 days to groups II, III, IV and V respectively while group I served as the control and were given distlilled water only. The animals were sacrificed at the expiration of the experiment after an overnight fast, brain, spleen and lungs were excised and the activities of hexokinase, aldolase, pyruvate kinase and lactate dehydrogenase were determined. Significant Increase in the activities of of all enzymes except lactate dehydrogenase were observed in a dose dependent manner in the animals when compared with the control (p< 0.05). In conclusion, aqueous extract of DS exhibit anti-hyperglycemic effects and might be a the mechanism behind its anti diabetic properties.