International Journal of Advanced Biochemistry Research

Biochem
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Vol. 8, Special Issue 4, Part F (2024)

Nephrotoxic effect of copper oxide nanoparticles in Wistar rats (Rattus norvegicus)

Author(s): Khevana A Thakore, Amit R Bhadaniya, Abdulkadir Makwana, Swati S Patel, Raj S Delvadiya, Harshad B Patel and Dhaval T Fefar
Abstract: CuO NPs (Copper oxide nanoparticles) are among the most commonly used nanomaterials. They have applications in different fields such as medicine, catalysis, sensing and textile industry. This NPs are released and accumulate in the environment causing adverse effects on the environment. Hence the study aimed to assess the impact of Copper oxide nanoparticles (CuO NPs) on Wistar rats following oral administration of CuO NPs. Forty-eight adult Wistar rats were divided into four groups: Group C (control), Group T1 (100 mg/kg), Group T2 (200 mg/kg) and Group T3 (400 mg/kg) and administrated CuO NPs for 28 days via oral gavage. Exposure of CuO NPs leads to significant alteration in percentage of neutrophils, monocytes and lymphocytes in higher dose group of both male and female rats also CuO NPs leads to significant alteration in Total Leukocyte Count (TLC) and platelet count in 400 mg/kg treated group in both male and female rats. There was significantly increased in level of markers of kidney damage Urea, Uric acid, Creatinine and Total protein in both male and female rats treated with high dose (400 mg/kg) of CuO NPs. CuO NPs exposure leads to significant reduction in SOD, CAT activity and significant increased MDA level in kidney of T3 (400 mg/kg) and T2 (200 mg/kg) group of both male and female rats. In histopathological examination treatment related changes were observed in dose dependent manner.
Pages: 431-440  |  145 Views  56 Downloads


International Journal of Advanced Biochemistry Research
How to cite this article:
Khevana A Thakore, Amit R Bhadaniya, Abdulkadir Makwana, Swati S Patel, Raj S Delvadiya, Harshad B Patel, Dhaval T Fefar. Nephrotoxic effect of copper oxide nanoparticles in Wistar rats (Rattus norvegicus). Int J Adv Biochem Res 2024;8(4S):431-440. DOI: 10.33545/26174693.2024.v8.i4Sf.1003
International Journal of Advanced Biochemistry Research
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