International Journal of Advanced Biochemistry Research

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Vol. 8, Special Issue 4, Part E (2024)

Evaluation of serum biochemical and anti-cancerous activity of Neolamarckia cadamba against DMBA induced in Wistar rats

Author(s): Mayur Purankar, Alka Sawarkar, Somkuwar AP, Madhuri Hedau, Manoj Patil and Swati Umap
Abstract: Neolamarckia cadamba is a medicinal plant reported for various medicinal properties. Anticancer activity of methanolic extract of stem bark of Neolamarckia cadamba on DMBA-induced diabetes and serum biochemical studies were conducted in Wistar rats. Group T1 is designated as the standard control, Group T2 was positive control, i.e. orally administered with DMBA at a dose rate of 20 mg/kg body weight three times a week for five weeks, Group T3 was treated with the standard reference drug Tamoxifen at a dose rate of 3.3 mg/kg body weight and Groups T4 and T5 were treated with methanolic bark extract of Neolamarckia cadamba at a dose rate of 200 and 400 mg/kg body weight, respectively. The observation obtained from ultrasonography examination of rats after the completion of treatment revealed that all the treatment groups (T3, T4, T5) showed that there was regression of the mammary tumour. On the 30th day, Tamoxifen @ 3.3 mg/kg decreases (p<0.05) the BUN and serum protein levels effectively compared to the T4 and T5. It is noticed that the T2 group positive control showed a steady increase in estrogen and progesterone levels, while the T3 group showed a significant decline as compared to the T4 and T5. The Std reference drug tamoxifen group showed effectiveness compared to the Neolamarckia cadamba extract dosages 200 mg/kg (T4) and 400 mg/kg (T5).
Pages: 382-386  |  123 Views  59 Downloads


International Journal of Advanced Biochemistry Research
How to cite this article:
Mayur Purankar, Alka Sawarkar, Somkuwar AP, Madhuri Hedau, Manoj Patil, Swati Umap. Evaluation of serum biochemical and anti-cancerous activity of Neolamarckia cadamba against DMBA induced in Wistar rats. Int J Adv Biochem Res 2024;8(4S):382-386. DOI: 10.33545/26174693.2024.v8.i4Se.1016
International Journal of Advanced Biochemistry Research
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