International Journal of Advanced Biochemistry Research

Biochem
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Vol. 8, Issue 4, Part A (2024)

Optimizing cisplatin dosage for intra lesional administration in bovine squamous cell carcinoma: A comprehensive study in livestock farming

Author(s): PL Parmar, PT Sutaria, SH Raval, PB Patel, MJ Desai and AC Patel
Abstract: Livestock farming is integral to the livelihoods of Indian farmers, but it is often impacted by bovine squamous cell carcinoma (SCC), a common malignant neoplasm characterized by uncontrolled squamous cell proliferation. This cancer typically originates from epithelial tissues, particularly those exposed to sunlight or chronic irritation. SCC predominantly affects areas such as the eyelids, vulva, prepuce, and regions around the eyes and muzzle. Treatment options for bovine SCC vary depending on factors like tumour location, size, and extent, with surgical excision, cryosurgery, laser ablation, and topical therapies being employed for localized lesions. In cases of advanced or metastatic disease, systemic chemotherapy or radiation therapy may be considered. Drawing from insights in human medicine, where cisplatin has been extensively studied in the context of squamous cell carcinoma treatment due to its effectiveness in disrupting tumour cell DNA and inducing apoptosis in those cells. Present study was conducted on bovines diagnosed with SCC to establish the appropriate dosage of cisplatin for intralesional administration following tumour removal. The precise dosing of cisplatin emulsified in sesame oil for post-tumour excision treatment was facilitated by carefully considering assumed shapes to calculate the volume of surgical beds, ensuring accurate administration of the chemotherapeutic agent. Additionally, proactive measures like obtaining written consent from owners to prohibit milk consumption for 14 days post-chemotherapy administration were implemented to safeguard public health and the well-being of other animals. This comprehensive approach to bovine SCC management emphasizes the importance of tailored treatment strategies and proactive measures in ensuring successful outcomes and minimizing adverse effects.
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International Journal of Advanced Biochemistry Research
How to cite this article:
PL Parmar, PT Sutaria, SH Raval, PB Patel, MJ Desai, AC Patel. Optimizing cisplatin dosage for intra lesional administration in bovine squamous cell carcinoma: A comprehensive study in livestock farming. Int J Adv Biochem Res 2024;8(4):01-06. DOI: 10.33545/26174693.2024.v8.i4a.886
International Journal of Advanced Biochemistry Research
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