International Journal of Advanced Biochemistry Research

Biochem
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Vol. 8, Special Issue 3, Part F (2024)

Effect of tributyltin exposure on the eye of zebrafish

Author(s): Rajkumar S Delvadiya, Urvesh D Patel, Abdulkadir A Makwana, Swati S Patel, Khevana A Thakore, Bhavesh J Trangadia and Harshad B Patel
Abstract: Tributyltin (TBT), as an organotin substance, is recognized as one of the important xenobiotic pollutants. The present study was carried out to investigate the toxicological effects of TBT on the sensory organ eye of adult female zebrafish. Adult zebrafish were exposed to three concentrations of TBT for 28 days (125, 250, and 500 ng/L) to evaluate the oxidative stress markers and histological changes in the eye. Mortality was not observed in any toxicity group. TBT exposure at 250 and 500 ng/L significantly decreased the CAT activity and total antioxidant capacity (TAC) of eye tissue. The higher levels of TBT exposure (250 and 500 ng/L) significantly increased lipid peroxidation as indicated by increased levels of MDA. Histopathological evaluation of the retina of adult zebrafish following TBT exposure at the highest concentration revealed mild depigmentation of the retinal pigmented epithelium layer.
Pages: 476-481  |  161 Views  65 Downloads


International Journal of Advanced Biochemistry Research
How to cite this article:
Rajkumar S Delvadiya, Urvesh D Patel, Abdulkadir A Makwana, Swati S Patel, Khevana A Thakore, Bhavesh J Trangadia, Harshad B Patel. Effect of tributyltin exposure on the eye of zebrafish. Int J Adv Biochem Res 2024;8(3S):476-481. DOI: 10.33545/26174693.2024.v8.i3Sf.794
International Journal of Advanced Biochemistry Research
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