Author(s): PL Parmar, PT Sutaria, SH Raval, PB Patel, MJ Desai, AC Patel and PG Solanki

Abstract: The dairy industry is pivotal for the livelihoods of farmers, with dairy cattle serving as their primary asset. However, tumours affecting cattle not only compromise their appearance but also raise welfare concerns, particularly squamous cell carcinomas (SCCs), which are prevalent among domestic animals in their productive years. In regions like India, where small-scale and marginal farmers dominate, mixed agriculture is crucial for sustenance. Here, SCCs pose a threat to annual earnings, especially since the vulvar and ocular regions are susceptible to these carcinomas. Ocular and vulvar tumours are notably common among animals raised with semi-intensive management and grazing access. Cancer is characterized by uncontrolled cell proliferation; hence, it remains a longstanding concern, especially due to post-surgical recurrence. This underscores the need for additional therapy. Considering cisplatin's cytotoxic mechanisms, including DNA damage and apoptosis induction, this makes it effective against various cancers and hence can turn out to be useful in preventing reoccurrence in bovine SCC. Therefore, a study was conducted to investigate the effects of intralesional cisplatin administration on biochemical parameters in bovines with SCCs. Results showed fluctuation in biochemical parameters but within normal ranges, suggesting intralesional cisplatin administration as adjunct therapy after excision did not notably affect these parameters. However, postoperative complications, such as abscess formation at the surgical site, were observed in animals treated with a cisplatin-sesame oil emulsion.

DOI: 10.33545/26174693.2024.v8.i3i.853