Abstract:Background: The current investigation was planned based on the aforementioned details. The aim of the study was to enhance the screening procedure and evaluate the efficacy of specific plants as antidiabetic and reduces the diabetes originated microvascular complications like neuropathy. Once the most effective technique has been identified, the parameters used to validate the models will be used to scientifically establish the antidiabetic effect(s).The research was conducted to create an anti-diabetic polyherbal formulation from an ethanol extract of Azadirachta indica leaves, Cinnamomum zeylanicum bark, Terminalia bellirica fruits, and Withania somnifera roots.
Method: For determining the Polyherbal preparation as normoglycemic and reduces the diabetes originated neuropathy the experimental model was designed, dose determination acquired by acute toxicity method of OECD guidelines. Dose for the test group is 100 mg/Kg, 200 mg/Kg and 400 mg/Kg and compared with Glibenclamide 10 mg/Kg as standard group.
Results: Our finding explains that the polyherbal extract at different doses shows hypoglycemic. The result obtains in the form of data showed that the preparation treats neuropathy acquired due to diabetes complications. Based on these findings, it is possible that this polyherbal extract could serve as the basis for the development of a novel Antidiabetic medication.
Conclusion:Biochemical and microscopic examinations of tissue sections provide evidence to the polyherbal formulation's stated therapeutic effects. In-vitro antioxidant activities and In-vivo efficacy of the combination proves that it provides better option to treat diabetes and its micro and macro complications.
