International Journal of Advanced Biochemistry Research

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Vol. 8, Special Issue 1, Part K (2024)

In-depth analysis of deleterious non-synonymous SNPs in the bovine ANPEP gene and their structural consequences

Author(s): Gaurav Patel, Ayushi Singh, Ymberzal Koul, Utsav Surati and Sachin Patidar
Abstract: This study delves into the genetic variations within the Aminopeptidase N (ANPEP) gene in cattle, focusing on missense variants and their potential impact on protein structure, stability, and function. A dataset containing SNPs was retrieved from Ensembl-Biomart and Uniprot databases. Deleterious non-synonymous SNPs were identified using SIFT, PANTHER, POLYPHEN-2, PhDSNP, PredictSNP, and SNAP2. The study also predicts the structural and functional consequences of these SNPs using I-Mutant 2.0, MUPRO, mCSM, and HOPE. Furthermore, protein-protein interaction analysis was conducted using STRING. Results reveal a set of common deleterious variants with potential implications for protein stability. The study enhances our understanding of genetic variations in the ANPEP gene in cattle, offering insights into potential functional consequences.
Pages: 839-844  |  342 Views  165 Downloads


International Journal of Advanced Biochemistry Research
How to cite this article:
Gaurav Patel, Ayushi Singh, Ymberzal Koul, Utsav Surati, Sachin Patidar. In-depth analysis of deleterious non-synonymous SNPs in the bovine ANPEP gene and their structural consequences. Int J Adv Biochem Res 2024;8(1S):839-844. DOI: 10.33545/26174693.2024.v8.i1Sk.456
International Journal of Advanced Biochemistry Research
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