For study on estimation of serum enzyme (AST, ALT, GGT and ALP) was conducted on 67 serum samples (10 serum samples collected from healthy goat as control group and 57 serum samples from affected goat that were showing various hepatic lesion) in and around Bikaner district. In comparison with healthy control group of goat, the value of AST, ALT, GGT and ALP was highly significant (p<0.01) increase in various hepatic lesion. While highly significant increase (p<0.05) in GGT was observed in congestion as compared to liver of control group of healthy animal.