Abstract: Fipronil is a phenyl pyrazole, broad-spectrum insecticide, used for control of pests in veterinary and agriculture sector. Present study was designed to evaluate the toxicity of fipronil following daily dermal application in Albino rats for 28 days. Rats were divided in to three groups having six animals in each group. Group I was treated as control and rats in group II and III were dermally applied with fipronil at dose 100 and 200 mg.kg-1 b.wt. Respectively daily for 28 days. Hematological and biochemical parameters were determined at 0, 14th and 28th day of exposure. The present investigation resulted in significant elevation in aspartate amino transaminase, alanine amino transaminase, alkaline phosphatase, lactate dehydrogenase activities in fipronil treated rats at both dose levels, indicated liver damage Fipronil also induced kidney damage as evidenced by significant increase in blood urea nitrogen and creatinine level. Also, the effect of fipronil on biochemical parameters was dose dependent. However, no significant changes on hematological parameters were observed at both the doses of fipronil during exposure period. Present study suggests hepatic and renal toxicity potential of fipronil following repeated dermal exposure.
