Potential neuroprotective effect of Lauric acid on rotenone: Induced Parkinson's disease in experimental rats

Hadeer S Abo Asi; Amira K El Tokhy; Hanaa H Gaballah; Hala M Hamooda; Nadia E Alashwah

doi:10.33545/26174693.2023.v7.i2d.261

Potential neuroprotective effect of Lauric acid on rotenone: Induced Parkinson's disease in experimental rats

Author(s): Hadeer S Abo Asi, Amira K El Tokhy, Hanaa H Gaballah, Hala M Hamooda and Nadia E Alashwah

Abstract: Background: Parkinson's disease (PD) is a chronic neuro-degenerative condition characterized by impaired motor function. It is defined by a lack of dopamine in the brain and the specific degradation of dopaminergic neurons in the Substantia Nigeria. The objective of this research was to examine the regulatory impact of Lauric acid (LA) on mitochondrial biogenesis in a rat model of rotenone-induced PD.

Materials and methods: this experiment has been carried out on sixty albino male rats categorized into 4 groups; group І (control group), group II (LA-treated group) and group IIІ (Rotenone-administered group) and Group IV (Rotenone and LA-treated group). Each group underwent catalepsy test neurobehavior and measurement of the protein carbonyl content (PCC) and (parkin interacting substrate) PARIS levels in brain tissue homogenate.

Results: This study showed that LA has significantly improved the locomotor activity in PD group with decreased PC and PARIS levels in brain tissue homogenate.

Conclusion: LA improves mitochondrial biogenesis, and possesses antioxidant effects in experimentally induced PD.

DOI: 10.33545/26174693.2023.v7.i2d.261

Pages: 281-285 | 252 Views 91 Downloads

download (995KB)