The most often utilized restorative material is dental amalgam. It has existed for more than 150 years. Dental amalgam is an amalgam of silver and mercury. Silver, tin, copper, and occasionally zinc are the main ingredients of the fine powder that constitutes the silver alloy. Dental amalgam is produced as a consequence of a chemical process involving silver alloy and mercury. When alloy and mercury interact, an amalgamation reaction takes place. The mercury in amalgam is chemically bonded to the other metals, making it stable and safe for use in dental applications even though some types of mercury are hazardous. In the current investigation, 50 samples were taken from participants who had dental fillings, and 50 samples were taken from those who did not. According to the study's findings, there are a total of 25.6 ± 3.40 mean micronuclei in the control group and 78.8 ± 7.08 mean micronuclei in the sick group. These results suggest that epithelial cell genetic damage may be estimated using the micronucleus test.