Background: The role of D-dimer and H-FABP as diagnostic markers in myocardial infarction (MI) is still a question. We aim to investigate the usefulness of D-dimer and H-FABP determination for the evaluation of myocardial infarction patients.
Methods: Forty patients with MI and 40 controls with a mean age of (57.37 ± 8.27), (57.47±8.329) were conducted. D-dimer, H-FABP, and troponin I tests were determinate at admission using Up-Converting Phosphor Quantitative Immunoassay Analyzer.
Results: D-Dimer and H-FABP concentrations were greater significantly in MI patients than controls, as was cTnI level (p<0.001). The cut-off values of D-dimer, H-FABP, and troponin I for diagnosis of MI were 425ng/ml, 4.1 ng/ml, and 0.105 ng/ml respectively with. The sensitivity and specificity of D-dimer was 82.5.% and 65.0%, for H-FABP it was 77.5%, and 57.5% and for cTnI it was 82.5% and 62.5%, respectively for diagnosis of MI.
Conclusions: D-dimer as a biomarker for the early diagnosis of MI would be the ideal combination with cTnI to cover the complete diagnostic for MI.