International Journal of Advanced Biochemistry Research

Biochem
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International Journal of Advanced Biochemistry Research

Vol. 6, Issue 2, Part B (2022)

Co-evaluation of magnesium and 25-hydroxyvitamin D3 in predicting the severity of COVID-19 disease

Author(s): Adem Keskin, Recai Aci, Emine Altin and Utku Duran
Abstract:
The severity of COVID-19 disease ranges from asymptomatic to severe, life-threatening symptoms. The aim of our study was to co-evaluate magnesium and 25-hydroxyvitamin D3 in predicting the severity of this disease.
This study included 232 inpatients with COVID-19 and 250 healthy individuals (control group). Magnesium and 25-hydroxyvitamin D3 levels were compared. ROC curve analysis was performed by co-evaluation of magnesium and 25-hydroxyvitamin D3 levels. Correlation analysis was performed between co-evaluation of magnesium and 25-hydroxyvitamin D3 levels together and the laboratory parameters used in the prognosis of COVID-19 disease.
Magnesium and 25-hydroxyvitamin D3 levels of the group with COVID-19 were lower than the control group (p< 0.001). AUC value was found to be 0.924 in ROC curve analysis (p< 0.001). In the ROC curve analysis, the cut-off value for magnesium was found to be 2.20, and the cut-off value for 25-hydroxyvitamin D3 was found as 25.80. Co-evaluation of magnesium and 25-hydroxyvitamin D3 levels were negatively correlated with D-dimer, C reactive protein, procalcitonin, neutrophil lymphocyte ratio and monocyte lymphocyte ratio (P< 0.05).
Co-evaluation of magnesium and 25-hydroxyvitamin D3 may be useful in predicting the severity of the disease in patients with COVID-19. Low magnesium and 25-hydroxyvitamin D3 levels can be considered a risk factor in patients with COVID-19. People with magnesium and 25-hydroxyvitamin D3 deficiencies may be considered at risk for COVID-19 disease. We recommend monitoring of magnesium and 25-hydroxyvitamin D3 levels to predict the prognosis of the COVID-19 disease. Individuals may be offered prophylactic magnesium and 25-hydroxyvitamin D3 supplementation.
Pages: 89-93  |  344 Views  139 Downloads
How to cite this article:
Adem Keskin, Recai Aci, Emine Altin, Utku Duran. Co-evaluation of magnesium and 25-hydroxyvitamin D3 in predicting the severity of COVID-19 disease. Int J Adv Biochem Res 2022;6(2):89-93. DOI: 10.33545/26174693.2019.v3.i1a.108
International Journal of Advanced Biochemistry Research