Author(s): Ako Alwell Chinonso, Nweje-Anyalowu Paul Chukwuemeka, Ejiofor Emmanuel Uchenna, Chigbu Charles Chukwuemeka and Ebere Wisdom Onyedikachi

Abstract: Mappianthus iodoides is a plant remedy exploited in the management of various microbial infections and it is also useful in reducing pain. The present study screened the leaf extracts of Mappianthus iodoides for its phytochemical constituents, anti-microbial and in vitro anti-inflammatory activities. Heat- and hypotonic induced haemolysis of red blood cells were used to access the anti-inflammatory activities and the anti-microbial activity was determined by the agar well diffusion method. The plant extracts were screened for qualitative phytochemical constituents and the presence of alkaloids, flavonoids, tannins, cardiac glycosides, phenols, steroids, amino acids, anthraquine and soluble carbohydrates were observed. The results showed that the extracts had significant inhibition of microbial growth against all the organisms tested. The minimum inhibitory concentration (MIC) of the extracts showed that almost all the organisms tested were responsive to the extracts at a given concentration. Also, the extracts significantly (p<0.05) and dose dependently decreased the haemolysis of erythrocyte membrane induced by heat and water. The activities recorded substantiate the ethno-medicinal claims of the plant.

DOI: 10.33545/26174693.2021.v5.i2a.74