Aim: To evaluate serum estradiol levels in pre and postmenopausal women with breast cancer.

Method: The breast cancer female patients were recruited from OPD/IPD of Surgery and Oncology department of SMS Hospital, and evaluated serum estradiol. Patients were divided into two group’s premenopausal and postmenopausal women with breast cancer.

Results: Serum estradiol levels are significantly high in postmenopausal women as compared to premenopausal women with breast cancer. The result was significantly higher (p<0.001).

Conclusion: Serum Estradiol levels can predict breast cancer in postmenopausal women. The risk of breast cancer increases with an increase in estradiol levels in postmenopausal women.