Method: The study includes diabetic patients visiting the Medicine OPD and was divided into groups according to the duration of diabetes. Group 1 with diabetes between 5-10 years, group 2 with diabetes between 10-15 years, group 3 with diabetes more than 15 years and control group.

Results: Serum cystatin-C and VEGF levels raised significantly in group 2 patients (10-15 years duration) and increases further with the progression of the disease.

Conclusion: Both cystatin-C and vascular endothelial growth factors can be a useful marker of early diabetic nephropathy in patients with type 2 diabetes