Fasting and non-fasting lipid profile: A comparative study
Author(s): Dr. Vittal BG and Dr. Abhijith D
Abstract: Sedentary lifestyle and lack of physical activity predisposes to Hyperlipidaemia which is a modifiable risk factor for coronary artery disease. The deranged lipid profile is also seen in patients of hypertension and diabetes mellitus which are among the most common non communicable diseases seen mainly in developed and some developing countries. Dyslipidemia depending upon the severity will be monitored by Lipid profile usually done in the fasting state and based on the differential derangement of lipid levels, treated accordingly. Most of the nations have switched on to non-fasting lipid profiles owing to its convenience and feasibility of testing and also probably considering the fact that the body is exposed to non-fasting lipid levels for most time in 24 hours of the day. This pilot study tried to compare and study the fasting and non-fasting lipid profile components by doing an observational cross-sectional study on 50 patients attending the Hassan Institute of Medical Sciences laboratory services, Hassan for regular health checkups. There was no statistically significant difference between total cholesterol, HDL cholesterol and LDL cholesterol in the fasting and postprandial state, whereas triglycerides and VLDL showed a significant statistical difference with a p-value less than 0.05. Our study concludes that non-fasting lipid profile is better both technically and operationally, with better diagnostic and prognostic capability with respect to monitoring and treatment of dyslipidaemias as compared to fasting lipid profile.