International Journal of Advanced Biochemistry Research

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International Journal of Advanced Biochemistry Research

Vol. 4, Issue 2, Part A (2020)

Evaluation of the extracts of Xylopia villosa Chipp (Annonaceae) on the lipid profile of rats rendered diabetic by streptozocin

Author(s): Kouame Yao Yves, Okpekon Aboua Timothée and Yapi Houphouët Félix
Abstract: The objective of this study was to assess the anti-lipid-lowering effect of extracts from the bark of Xylopia villosa stems in rats made diabetic by streptozocin. Daonil® 20 mg/kg body weight reduced the total cholesterol concentration in the same way (P ˃ 0.05) as the hydroethanolic extract 200 mg/kg body weight. The triglycerides concentration (1.68 ± 0.10 g/L) of diabetic rats treated with hydroethanolic extract 200 mg/kg body weight became similar (P ˃ 0.05) to that (1.34 ± 0.01 g/L) of non-diabetic control rats. Aqueous extract at a dose of 200 mg/kg body weight normalized (P ˃ 0.05) HDL cholesterol concentration while hydroethanolic extract at a dose of 200 mg/kg body weight, it strictly increased (P <0.001) the concentration of HDL-cholesterol. Aqueous and hydroethanolic extracts at a dose of 200 mg/kg body weight lowered LDL cholesterol concentration in diabetic rats in the same way (P ˃ 0.05).
Pages: 28-32  |  149 Views  57 Downloads
How to cite this article:
Kouame Yao Yves, Okpekon Aboua Timothée, Yapi Houphouët Félix. Evaluation of the extracts of Xylopia villosa Chipp (Annonaceae) on the lipid profile of rats rendered diabetic by streptozocin. Int J Adv Biochem Res 2020;4(2):28-32. DOI: 10.33545/26174693.2020.v4.i2a.53
International Journal of Advanced Biochemistry Research