Vol. 4, Issue 2, Part a (2020)

Abstract: The objective of this study was to assess the anti-lipid-lowering effect of extracts from the bark of Xylopia villosa stems in rats made diabetic by streptozocin. Daonil^® 20 mg/kg body weight reduced the total cholesterol concentration in the same way (P ˃ 0.05) as the hydroethanolic extract 200 mg/kg body weight. The triglycerides concentration (1.68 ± 0.10 g/L) of diabetic rats treated with hydroethanolic extract 200 mg/kg body weight became similar (P ˃ 0.05) to that (1.34 ± 0.01 g/L) of non-diabetic control rats. Aqueous extract at a dose of 200 mg/kg body weight normalized (P ˃ 0.05) HDL cholesterol concentration while hydroethanolic extract at a dose of 200 mg/kg body weight, it strictly increased (P <0.001) the concentration of HDL-cholesterol. Aqueous and hydroethanolic extracts at a dose of 200 mg/kg body weight lowered LDL cholesterol concentration in diabetic rats in the same way (P ˃ 0.05).