Introduction: Chronic kidney disease (CKD) now a day becomes an emerging condition with increasing morbidity and mortality. CKD associated with disturbances in alkaline phosphatase levels significantly alters in stage 4 and 5. Serum ALP levels have been shown to have a promoting effect on vascular calcification. So, correlation of ALP with renal failure is also well established.

Aim: To compare the level of serum ALP, urea and creatinine among the CKD patients and healthy controls.

Materials and method: About 50 CKD patients in stage 4 & 5 in dialysis unit and 50 healthy subjects between the age group 30-60 yrs were included in this study carried out from May2018 to January2020 at Noor hospital and IIMSR Medical College, Warudi, Maharashtra. Serum level of ALP, urea and creatinine were measured by fully autoanalyzer. Statistical analysis is done by minitab version 17 software.

Results and conclusion: The results are presented as a mean ±SD and ‘P’ values of less than 0.05% is considered as significant. In our study ALP, urea and creatinine are increased in stage 4 and 5 CKD patients.