International Journal of Advanced Biochemistry Research
Vol. 4, Issue 1, Part A (2020)
Role of serum levels of vitamin D in patients of breast Cancer
Author(s): Dr. Luna Sinha, Dr. Ashuma Sachdeva and Dr. Nityasha
Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females. Breast cancer is a hormone dependent disease which occurs due to hyperestrogenic states.
Aim and Objectives: To study the role of serum levels of vitamin D in patients of breast cancer and age matched control subjects along with comparison of lymph node positive and negative patients of breast cancer.
Material and Methods: A total of 30 newly diagnosed patients of breast cancer with thirty age matched subjects as controls were included in the study. Serum was analysed for vitamin D levels by RIA Analyser SR300 method in both the groups.
Results: The mean serum vitamin D level was significantly lower in cases as compared to controls (p<0.001). Vitamin D deficiency was found to be significantly higher in cases i.e. 80% than in controls i.e. 13.3% (p<0.0001). The mean serum vitamin D level was also comparable between lymph node positive and negative (p=0.934, p>0.05) cases.
Conclusion: Vitamin D had anticarcinogenic effect due to their participation in regulating cell proliferation, differentiation and apoptosis in normal and malignant breast cells.