Role of serum levels of vitamin D in patients of breast Cancer
Author(s): Dr. Luna Sinha, Dr. Ashuma Sachdeva and Dr. Nityasha
Abstract:
Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females. Breast cancer is a hormone dependent disease which occurs due to hyperestrogenic states.
Aim and Objectives: To study the role of serum levels of vitamin D in patients of breast cancer and age matched control subjects along with comparison of lymph node positive and negative patients of breast cancer.
Material and Methods: A total of 30 newly diagnosed patients of breast cancer with thirty age matched subjects as controls were included in the study. Serum was analysed for vitamin D levels by RIA Analyser SR300 method in both the groups.
Results: The mean serum vitamin D level was significantly lower in cases as compared to controls (p<0.001). Vitamin D deficiency was found to be significantly higher in cases i.e. 80% than in controls i.e. 13.3% (p<0.0001). The mean serum vitamin D level was also comparable between lymph node positive and negative (p=0.934, p>0.05) cases.
Conclusion: Vitamin D had anticarcinogenic effect due to their participation in regulating cell proliferation, differentiation and apoptosis in normal and malignant breast cells.
Dr. Luna Sinha, Dr. Ashuma Sachdeva, Dr. Nityasha. Role of serum levels of vitamin D in patients of breast Cancer. Int J Adv Biochem Res 2020;4(1):37-41. DOI: 10.33545/26174693.2020.v4.i1a.69