International Journal of Advanced Biochemistry Research

Biochem
Journal

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International Journal of Advanced Biochemistry Research

Vol. 4, Issue 1, Part A (2020)

Role of serum levels of vitamin D in patients of breast Cancer

Author(s): Dr. Luna Sinha, Dr. Ashuma Sachdeva and Dr. Nityasha
Abstract:
Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females. Breast cancer is a hormone dependent disease which occurs due to hyperestrogenic states.
Aim and Objectives: To study the role of serum levels of vitamin D in patients of breast cancer and age matched control subjects along with comparison of lymph node positive and negative patients of breast cancer.
Material and Methods: A total of 30 newly diagnosed patients of breast cancer with thirty age matched subjects as controls were included in the study. Serum was analysed for vitamin D levels by RIA Analyser SR300 method in both the groups.
Results: The mean serum vitamin D level was significantly lower in cases as compared to controls (p<0.001). Vitamin D deficiency was found to be significantly higher in cases i.e. 80% than in controls i.e. 13.3% (p<0.0001). The mean serum vitamin D level was also comparable between lymph node positive and negative (p=0.934, p>0.05) cases.
Conclusion: Vitamin D had anticarcinogenic effect due to their participation in regulating cell proliferation, differentiation and apoptosis in normal and malignant breast cells.
Pages: 37-41  |  75 Views  18 Downloads
How to cite this article:
Dr. Luna Sinha, Dr. Ashuma Sachdeva, Dr. Nityasha. Role of serum levels of vitamin D in patients of breast Cancer. Int J Adv Biochem Res 2020;4(1):37-41. DOI: 10.33545/26174693.2020.v4.i1a.69
International Journal of Advanced Biochemistry Research