Introduction: Cardiovascular disease is the most frequent cause of adult death in industrial societies and is increasingly important in developing countries like India.

In the year 2000 the European Society of Cardiology and the American College of Cardiology Committee jointly redefined Myocardial Infarction (MI) by an elevation of cardiology troponin T (Trop T) and cardiac troponin (cTn) is diagnostic and high sensitivity of cTn for detection of even small amounts of myocardial necrosis. Presently Troponin are the most prominent biomarker of cardiac injury is 1st cardiac biomarker which a clinician can use at the bedside of the patient for risk stratification of cardiac injury and have relegated conventional biomarkers like CK-MB to 2nd place. This is so because Cardiac Troponic are highly cardiac tissue specific unlike conventional biomarkers.

Materials and Methods: Diagnosed ischemic heart disease (IHD) and hypertensive (HTN) patients were taken as cases, out of these divided into two groups of patients. The first group (n= 50) were patients with IHD including MI. The second group (n= 50) were patients with HTN and third group (n=50) were normal healthy control. In all 3 groups cTnT & CK-MB biochemical markers are evaluated.

Results: In all diseased two groups cTnT and CK-MB biochemical markers are elevated and in control healthy group CTnT & CK-MB are normal.

Conclusion: Small elevations of trop T identify minimal cardiac necrosis and patients can benefit from early invasive therapy. Trop T and CK-MB had an independent effect on long term survival and the combination of both is associated with even worse survival.