Serum urea and creatinine are most widely accepted parameters to assess renal impairment (CKD) in diabetes.
Aim: To assess e the serum Blood urea nitrogen, creatinine and protein levels in diabetes mellitus subjects to identify the renal impairments.
Materials and Methods: This cross-sectional study was done on 40 subjects involving 15 Type 1, 15 Type 2 diabetic and 10 healthy controls. After collection of blood samples, urea creatinine, blood sugar and proteins were analyzed by enzymatic and calorimetric method.
Results: In the present study, a total of n=40 diabetic subjects were included, out of which n=20 were male and n=20 were female subjects. The male to female ratio was 1:1. The age of the subjects ranged from 35 - 55 years and the mean age was 50.92 years. The age of the healthy controls ranged from 45 – 52 years and the mean age was 47.72 years. Mean value of Blood glucose (FBS) levels in type 2 diabetes and type were found to be (145.13±10.84; 152.2±9.03) whereas in control group was observed to be 110±7.91). The mean (±SD) value of creatinine in type 2 diabetes group were found to be (2.53±10.84), whereas in type 1 diabetes group were found to be (2.99±0.67). The mean value of creatinine in control group was observed to be 0.80±0.08. Thus, the mean blood urea and serum creatinine levels were statistically significantly (p≤0.05). Blood urea nitrogen in both the diabetic patients compared to healthy controls. (In type 2, 49.66±6.91; Type 1, 48.66±6.73 and in healthy controls was observed to be 10.91±1.68). Urine pH also slightly high in diabetic patients compared to healthy controls. Mean value of proteins in type 1 diabetes found to be 143.13±21.53; whereas in type 2 142.53±28.80. In healthy control subjects mean protein value was observed to be 114.2±3.04.
Conclusion: Strong relationship of blood urea and serum creatinine levels was found with blood sugar levels. Blood urea and serum creatinine levels along with blood glucose levels would be helpful to monitor the diabetes patients to assess renal function.