Author(s): Nweke Elizabeth Obioma, Akunne Wariso, Iheukwumere Chinedu Barry and Agu Esther

Abstract: The aim of this study was to evaluate the potential of ethanol leaf extract of Persea americana as a treatment option for renal damage. Freshly harvested leaves of P. Americana were processed into fine powder. 500 g of powdered plant sample was soaked in 70% ethanol for 72 hr and afterwards, sieved and concentrated. Twenty five adult male wistar rats were divided into five groups of five rats each. Group 1 was the normal control and was fed normal rat chow and water only. Group II was the negative control and was induced renal damage without treatment. Group III-V were induced renal damage and treated with 100, 300, 500 mg/kg b.w of extract orally respectively. Animals were sacrificed, after which blood sample was collected and kidney tissue harvested and analysed using standard procedures. The serum urea and creatinine levels of rats administered CCL₄ only was significantly (P< 0.05) higher than that reported for their treated counterparts. However, there was no significant (P> 0.05) difference in the urea and creatinine levels of rats treated with different doses of extract compared to their normal control counterpart. There was a significant (P< 0.05) body weight increase among treated groups. However, a contrary observation was made on group II induced renal damage without treatment. In conclusion, ethanol extract of Persea americana leaf has the potential to ameliorate renal damage.

DOI: 10.33545/26174693.2019.v3.i2a.102