Abstract: Background and objectives:
Chronic kidney disease is a global threat to health in general and for developing countries. It is characterized by progressive deterioration of kidney function which develops eventually into a terminal stage of chronic kidney failure. Leptin is an adipose tissue-derived hormone shown to be related to several metabolic, inflammatory, and hemostatic factors related to chronic kidney disease. The objective of the study is to understand the role of serum Leptin in chronic kidney disease.
Material and Methods: A case control study was done with 87 patients divided into 2 groups. 43 healthy individuals were served as controls and 44 chronic kidney disease patients were served as cases. Serum Leptin was estimated by ELISA method. Blood urea was estimated by urease method and serum creatinine by modified Jaffe‟s method. BMI was calculated. Data was analysed by using graph pad prism 7.0.
Results: In the present study, patients with chronic kidney disease had significant higher levels of serum Leptin (55.88 ± 31.59),blood urea (75.23 ± 30.91), serum creatinine is (4.09 ± 1.90) and BMI is (24.66 ± 2.667) when compared to healthy individuals serum Leptin levels is (7.91 ± 8.24), blood urea (27.53 ± 8.03), serum creatinine is (1.28 ± and BMI is (23.33 ± 2.45) with a p value < 0.001.
Conclusion: Serum Leptin levels were high in patients with chronic kidney disease when compared to healthy individuals even the BMI was in normal range in both patients and healthy individuals. The study concludes that serum Leptin is associated with chronic kidney disease and can be used as a marker for diagnosis and prognosis in chronic kidney disease.