Correlation of liver indices with thrombocytopenia in dengue infected children
Author(s): Dr. Aruna Kumari Bandaru and Divya Sai Vanumu
Abstract:Objective: To evaluate and correlate the early hepatic markers with thrombocytopenia that distinguishes the acute phase of dengue from other febrile illness.
Methods: Study includes 50 controls, 54 other febrile illness and 105 dengue infected children between 3 months to 15 years age group. Liver function tests and platelet count were analyzed.
Results: There was a significant elevation of transaminases, prothrombin time, activated partial thromboplastin time, ammonia with p<0.05 in dengue infection than other febrile illness and controls, but significant decrease in alkaline phosphatase and platelet count. C-reactive protein was significantly raised with P<0.05 in other febrile illness than dengue infection and controls.
Conclusion: During an acute phase of illness, raised aspartate transaminase, activated partial thromboplastin time and platelet count <50000/mm3, C-reactive protein were useful as early markers to differentiate dengue from other febrile illness.
Dr. Aruna Kumari Bandaru, Divya Sai Vanumu. Correlation of liver indices with thrombocytopenia in dengue infected children. Int J Adv Biochem Res 2019;3(1):15-20. DOI: 10.33545/26174693.2019.v3.i1a.27