International Journal of Advanced Biochemistry Research
Vol. 3, Issue 1, Part A (2019)
Correlation of liver indices with thrombocytopenia in dengue infected children
Author(s): Dr. Aruna Kumari Bandaru and Divya Sai Vanumu
Abstract:Objective: To evaluate and correlate the early hepatic markers with thrombocytopenia that distinguishes the acute phase of dengue from other febrile illness.
Methods: Study includes 50 controls, 54 other febrile illness and 105 dengue infected children between 3 months to 15 years age group. Liver function tests and platelet count were analyzed.
Results: There was a significant elevation of transaminases, prothrombin time, activated partial thromboplastin time, ammonia with p<0.05 in dengue infection than other febrile illness and controls, but significant decrease in alkaline phosphatase and platelet count. C-reactive protein was significantly raised with P<0.05 in other febrile illness than dengue infection and controls.
Conclusion: During an acute phase of illness, raised aspartate transaminase, activated partial thromboplastin time and platelet count <50000/mm3, C-reactive protein were useful as early markers to differentiate dengue from other febrile illness.