Introduction: This comprehensive study explores serum biomarkers and risk factors in non-diabetic ischemic stroke patients compared to healthy controls, shedding light on stroke pathogenesis and risk stratification.

Materials and Methods: Present study assessed serum homocysteine, high-sensitivity C-reactive protein (hs-CRP), and lipid profiles in a cohort of 30 subjects. Subgroup analyses were conducted based on age and gender, unraveling nuanced trends. Correlations between these biomarkers were scrutinized, revealing potential interplays. Furthermore, we delved into risk factors such as smoking, alcohol use, and family history of cardiovascular disease to provide a comprehensive risk profile.

Results: Our study unveils significant disparities in serum biomarkers between the two groups. Ischemic stroke patients exhibit elevated homocysteine and hs-CRP levels, unfavorable lipid profiles, and a higher prevalence of risk factors. Subgroup analyses delineate age and gender-specific differences, emphasizing age as a prominent risk factor, and women with stroke presenting distinct lipid profiles. The correlation analysis underscores complex relationships between biomarkers, offering insights into potential synergistic mechanisms. Moreover, our identification of smoking, alcohol use, and family history as significant risk factors reaffirms their critical roles in stroke susceptibility.

These findings underscore the multifaceted nature of ischemic stroke, necessitating tailored risk assessment and intervention strategies that consider age, gender, lifestyle factors, and the interplay between serum biomarkers. This comprehensive approach is imperative for effective stroke prevention and management.