Vitamin d and parathyroid hormone levels and their association with insulin resistance in type 2 diabetes subjects

Dr. Shubha Jayaram; Dr. MA Shekar; Dr. Meera S; Dr. Deepa K; Dr. Savitha Nageshappa; Dr. Srikanta BM

doi:10.33545/26174693.2020.v4.i1a.44

Vitamin d and parathyroid hormone levels and their association with insulin resistance in type 2 diabetes subjects

Author(s): Dr. Shubha Jayaram, Dr. MA Shekar, Dr. Meera S, Dr. Deepa K, Dr. Savitha Nageshappa and Dr. Srikanta BM

Abstract: Vitamin D deficiency is associated with metabolic diseases like Type-2 diabetes mellitus, obesity and insulin resistance. Previous studies have evaluated the effects of vitamin D and parathyroid hormone (PTH) separately in isolation rather than studying the combined effects of both hormones together as a reflection of the status of the PTH-Vitamin D axis. Low vitamin D coupled with increased PTH may be a better indicator, which is the novelty of the present study.

A total of 151 Type 2 diabetic subjects attending the outpatient clinics of endocrinology department of MMC&RI, Mysore, were chosen for the study. Vitamin D, PTH, calcitonin and Insulin levels were analysed using chemiluminescence Immuno assay techniques. Comparison was made between normal (vitamin D >20ng/ml) and vitamin D deficient (vitamin D <20ng/ml) groups. Significant increase in FBS, HbA1c, insulin levels and HOMA-IR value was seen in vitamin D deficient group (p<0.05). Vitamin D was negatively correlated with PTH, FBS, PPBS and HbA1c at p<0.01.

Significant vitamin D deficiency and increased PTH levels are seen in Type 2 diabetic subjects. Insulin resistance was more common among diabetic subjects having both vitamin D deficiency and elevated PTH when compared to those diabetics with isolated vitamin D or elevated PTH

DOI: 10.33545/26174693.2020.v4.i1a.44

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