Background: Hypothyroidism is associated with many biochemical abnormalities including increased serum creatinine, uric acid, and decreased serum zinc levels. Many studies were done abroad regarding serum creatinine and uric acid levels in hypothyroid patients. We designed this study in our population for evaluation and comparison of serum creatinine, uric acid, and zinc levels in hypothyroid and healthy patients.

Aim & Objective of the study: The main aim of the current study is to estimate and comparison of changes in serum creatinine, uric acid and zinc levels in hypothyroid patients and healthy controls.

Materials and Methods: It is an observational prospective comparative study. This study was conducted at Mamatha Academy of Medical Sciences & Hospital, Bachupally, Hyderabad, Telangana from January 2019 to July 2019. There were 50 cases and 50 controls in the age groups from 18 to 65 years. Fresh samples were taken and required tests were performed following standard protocol. Creatinine and the uric acid level was estimated by semi auto analyzer and zinc level was estimated by atomic absorption spectrophotometer

Results: In the present study, mean serum creatinine and uric acid levels in cases were 3.20± 0.65 and 9.20 ± 0.47 mg/dL respectively compared to 1.04 ± 0.22 and 5.15 ± 0.77 mg/dL in controls. Mean serum zinc levels in cases were 62.50±7.50 mg/dL compared to 95.45±11.05 mg/Dl in controls. The level of serum creatinine and uric acid were significantly high and serum zinc was significantly low (p-value<0.0001) in hypothyroid patients compared to healthy controls.

Conclusion: Mean serum creatinine and uric acid levels were found significantly higher in hypothyroid patients compared to controls. It leads to a reduction in renal plasma flow and glomerular filtration rate and low serum zinc was found due to impaired gastrointestinal absorption of zinc in hypothyroid subjects or change in zinc distribution due to sequestration of zinc by the liver. These findings suggest that hyperuricemia and hypercreatininemia are associated with hypothyroidism. Therefore, patients presenting with these biochemical abnormalities are recommended to be investigated to explore hypothyroidism.